SYNTHESIS AND BIOLOGICAL STUDIES OF AROYL THIOUREA AND 2,2,6,6- TETRAMETHYL-4-OXOPIPERIDINIUM 4-CHLORO-3-NITROBENZOATE

Abstract

The reaction of benzoylchloride, o-,m-,p-methylbenzoylchloride, o-,m- and p- nitrobenzoylchloride with ammonium thiocyanate followed by pyrrolidine all gave the corresponding N-(aroyl)-N’-(pyrrolidine-1-yl)thiourea. However, the same reaction but with 4- chloro-3-nitrobenzoyl chloride was found to give 2,2,6,6-tetramethyl-4 oxopiperidinium 4- chloro-3-nitrobenzoate. All the compounds were confirmed by elemental analysis. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), UV-Vis and one of the synthesized compounds are analyzed by X ray single crystal diffraction technique. The biological studies of the thiourea derivatives compounds were tested against a few types of bacteria and the results showed no activity against Methicilin Resistant Staphylococcus aureus (MRSA), S.Pyogenes, P.mirabilis and Enterobacter aerogenes. On the other hand, the ionic salt was active against all the bacteria.